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Manufacturer and Exporter of Herbal Extract

In stock

Piper Nigrum Extract

Black Pepper- Piper nigrum, is one of the most popular spice used all over the world. Commonly known as Kaali Mirch in India, Black Pepper is a dried form of unripened green berries. Major alkaloids present in Black Pepper are Piperine, Chavicine, and Piperidine. The Bioactive component Piperine has potent antioxidant properties. Black Pepper is rich in Vitamin A and K in addition to dietary fibers, Calcium, Magnesium, Potassium, Manganese, Phosphorus, and Beta-carotene.

Botanical Name– Piper nigrum

Plant Part Used– Fruits

Active Constituents– Piperine

Specifications

  • Black Pepper Extract 95% Piperine (HPLC)

Benefits

  • High In Antioxidants
  • Manages Blood Sugar Level
  • Healthy Cholesterol Level
  • Supports Digestion

Category:

Description

Piper nigrum L. is commonly used as a traditional medicine and food in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of P. nigrum on allergic rhinitis (AR) has been unclear. In the present study, an OVA-induced AR mice model were established to investigate the anti-allergic, anti-inflammation properties of P. nigrum fruit extract (PNE). Oral administrations of PNE inhibited the allergic nasal symptoms including rubbing and sneezing in the early-phage of AR. In both NALF and nasal tissue, PNE suppressed the inflammatory cells accumulation, specifically with eosinophils in NALF. Additionally, PNE prevented the activation of STAT3 and NFκBp65 signaling in the cytoplasm which led to increasing the synthesis of the anti-inflammatory Th1 cytokines and suppressing the inflammatory Th2, Th17 cytokines. These obtained results suggest that PNE has the promising strategy for immunotherapy in allergic rhinitis disease.

Keywords: Allergic rhinitis; Eosinophil; NFκBp65; Nasal epithelium; Piper nigrum; STAT3.

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